abstract：BACKGROUND:Reconstruction after excision of the humeral malignancy is a challenging issue for the reconstructive surgeon. The combined use of a fibular flap and allograft can provide a reliable reconstructive option. This article describes the authors' experience with this technique for the treatment of segmental bone ...

journal_title：Journal of surgical oncology

authors： Li J,Wang Z,Pei GX,Guo Z

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Previous in vitro studies have suggested that IGF-1 stimulation can lead a more aggressive breast cancers and subsequent poor prognosis in breast cancer patients. We aim to how IGF-1 and IGF-1R mRNA levels in breast cancer are associated with disease-free survival (DFS) and other clinicopathol...

journal_title：Journal of surgical oncology

authors： Chong KY,Subramanian A,Mokbel K,Sharma AK

更新日期：2011-09-01 00:00:00

abstract：:Most surgical oncologists receive exposure to clinical studies in their fellowships; however they receive little if any practical knowledge as to how to become a clinical researcher. This article will provide a broad introduction to setting up a community based surgical oncology research program with emphasis on the p...

journal_title：Journal of surgical oncology

authors： Beitsch P,Huber T

更新日期：2011-09-01 00:00:00

abstract：:Selective sentinel lymph node dissection (SLND) plays an important role in the staging of the regional nodal basins for head and neck (H&N) melanoma. Preoperative lymphoscintigraphy is mandatory to identify the regional nodal basin(s) accurately for a newly diagnosed H&N primary melanoma of at least 1mm or greater. A ...

journal_title：Journal of surgical oncology

authors： Leong SP

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Heme oxygenase-1 (HO-1) correlates with aggressive tumor behavior and chemotherapy resistance in pancreatic cancer (PC). We evaluated the prognostic value of the basal transcription controlling germ line GTn repeat polymorphism (GTn) in the promoter region of the HO-1 gene in PC. PATIENTS AND METHODS:We det...

journal_title：Journal of surgical oncology

authors： Vashist YK,Uzungolu G,Kutup A,Gebauer F,Koenig A,Deutsch L,Zehler O,Busch P,Kalinin V,Izbicki JR,Yekebas EF

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Patients with Stage IV melanoma have limited therapeutic options with few long-term survivors. Our goal was to study the impact of metastasectomy on survival in these patients. METHODS:Patients with Stage IV melanoma were identified from the Surveillance, Epidemiology, and End Results (SEER) database (198...

journal_title：Journal of surgical oncology

authors： Wasif N,Bagaria SP,Ray P,Morton DL

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether LAPTM4B over-expression is associated with the prognosis and chemotherapy resistance in patients with stages III and IV epithelial ovarian carcinoma, i.e., patients with peritoneal metastasis or lymph node metastasis of epithelial ovarian carcinoma. METHODS...

journal_title：Journal of surgical oncology

authors： Yin M,Li C,Li X,Lou G,Miao B,Liu X,Meng F,Zhang H,Chen X,Sun M,Ling Q,Zhou R

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease-free survival after curative resection of the primary tumor without adjuvant systemic therapy. METHODS:Paraffin-embedded tumor secti...

journal_title：Journal of surgical oncology

authors： Kern A,Görgens H,Dittert DD,Krüger S,Richter KK,Schackert HK,Saeger HD,Baretton G,Pistorius S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate the histopathological characteristics of gastric submucosal tumors (SMTs) according to their location. METHODS:A retrospective analysis of a prospective database of 151 consecutive patients who underwent surgery for gastric SMTs between 2001 and 2009 was performe...

journal_title：Journal of surgical oncology

authors： Lee HH,Hur H,Jung H,Jeon HM,Park CH,Song KY

更新日期：2011-07-01 00:00:00

abstract：:Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and locally aggressive tumor with poor prognosis. Currently, no standard therapy is available. The biology of this disease is still poorly understood. We performed a systematic search of relevant studies on clinical management and biological research of D...

journal_title：Journal of surgical oncology

authors： Baratti D,Kusamura S,Deraco M

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We evaluated the clinicopathological associations and prognostic implications of promyelocytic leukemia gene (PML) expressions in patients with esophageal squamous cell carcinomas (ESCC) receiving primary surgery. METHODS:Expression patterns of PML and tumor protein 53 (TP53) of 132 cases of ...

journal_title：Journal of surgical oncology

authors： Yen CC,Tsao YP,Chen PC,Wu YC,Liu JH,Pan CC,Liu CY,Tzeng CH,Chen PM,Chen YJ,Lin CH,Hsu WH

更新日期：2011-06-01 00:00:00

abstract：:Among women who have undergone surgery for breast cancer, the risk of recurrence, especially distant metastases, peaks 1-2 years postsurgery. Recent clinical trial evidence suggests that initial adjuvant therapy with an aromatase inhibitor (AI) can reduce this early risk of recurrence. According to the recently update...

journal_title：Journal of surgical oncology

authors： Doughty JC

更新日期：2011-06-01 00:00:00

abstract：:Most solid tumors have now been reported to contain stem cell-like cells called cancer stem cells (CSCs). These cells are endowed with high tumorigenic capacity and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. Since these self-renewing cancer cells may be the s...

journal_title：Journal of surgical oncology

authors： Li H,Tang DG

更新日期：2011-05-01 00:00:00

abstract：:Tumor-associated neovascularization allows tumor cells to express their critical growth advantage, whereas lymphatic invasion is crucial for the metastatic process. Various growth factors stimulate blood and lymphatic neovascularization and modulate vessel permeability in tumors. The first anti-angiogenic drugs are al...

journal_title：Journal of surgical oncology

authors： Holopainen T,Bry M,Alitalo K,Saaristo A

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This retrospective study evaluated the feasibility and effectiveness of type II radical hysterectomies alone, or in combination with adjuvant treatment, for the treatment of patients with stage IB-IIB cervical cancer with or without high-risk factors. METHODS:A total of 960 stage IB-IIB patie...

journal_title：Journal of surgical oncology

authors： Zheng M,Huang L,He L,Ding H,Wang HY,Zheng LM

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to present two series of cases of pigmented villonodular disease of joints (PVNS) treated at different periods. The 215 cases from our hospital are current (1972-2009) and those 62 from the Jaffe collection from 1920 to 1968. METHODS:By use of our computerized tumor data syste...

journal_title：Journal of surgical oncology

authors： Mankin H,Trahan C,Hornicek F

更新日期：2011-04-01 00:00:00

abstract：:Neoadjuvant systemic breast cancer therapy is the administration of systemic therapy to eligible breast cancer patients prior to surgery. This treatment modality was developed out of necessity to downstage inoperable tumors, but it has evolved into a tool for breast conservation surgery. The neoadjuvant approach is al...

journal_title：Journal of surgical oncology

authors： Makhoul I,Kiwan E

更新日期：2011-03-15 00:00:00

abstract：BACKGROUND:CD40 and CD154 are associated with lymphocyte signaling pathways and they are also expressed in some malignant neoplasms, but the significance in pancreatic cancer is unknown. METHODS:Eighty pancreatic cancer specimens were stained immunohistochemically, and the results were correlated with the patients' cl...

journal_title：Journal of surgical oncology

authors： Shoji Y,Miyamoto M,Ishikawa K,Yoshioka T,Mishra R,Ichinokawa K,Matsumura Y,Itoh T,Shinohara T,Hirano S,Kondo S

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma. Our goal was to study the surgical management of DM, identify prognostic factors, and impact of treatment options. METHODS:Patients with DM (n = 1,735) were identified from the Surveillance, Epidemiology, and End Results data...

journal_title：Journal of surgical oncology

authors： Wasif N,Gray RJ,Pockaj BA

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Arterial resection (AR) has traditionally been considered as a contraindication to pancreatic resection for locally advanced pancreatic adenocarcinoma. The objective was to evaluate if pancreatic resection with AR was worthwhile. METHODS:Between January 1990 and December 2008 the records of 2...

journal_title：Journal of surgical oncology

authors： Bachellier P,Rosso E,Lucescu I,Oussoultzoglou E,Tracey J,Pessaux P,Ferreira N,Jaeck D

更新日期：2011-01-01 00:00:00

abstract：:Up to 50% of patients with colorectal cancer will develop metastatic disease in the liver. While surgical extirpation remains the best option for long-term survival, several complementary modalities such as laparoscopy, radiofrequency ablation, and microwave coagulation have gained wide acceptance as primary and adjun...

journal_title：Journal of surgical oncology

authors： Rocha FG,D'Angelica M

更新日期：2010-12-15 00:00:00

abstract：:Liver metastasis represents a common systemic complication of colorectal cancers (CRCs). Partial liver resection has been demonstrated to result in long-term survival in certain well-selected patients with otherwise well-controlled systemic disease. Neoadjuvant therapy has been demonstrated to result in improved resec...

journal_title：Journal of surgical oncology

authors： Wanebo HJ,Berz D

更新日期：2010-12-15 00:00:00

abstract：BACKGROUND AND OBJECTIVES:B7-H4 is a novel molecular B7 ligand that plays an important role as a negative regulator of the T cell-mediated immune response. However, the clinical significance of B7-H4 expression in gastric cancer remains uncertain. Here, we assessed B7-H4 expression in blood of patients with gastric can...

journal_title：Journal of surgical oncology

authors： Arigami T,Uenosono Y,Hirata M,Hagihara T,Yanagita S,Ishigami S,Natsugoe S

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients. METHODS:One hundred and forty one cases of NPC and 25 normal tissues...

journal_title：Journal of surgical oncology

authors： Liao B,Zhong BL,Li Z,Tian XY,Li Y,Li B

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Due to their rare incidence soft tissue sarcomas (STS) are often resected without clear margins. The aim of this study was to investigate the impact of re-excision of STS on survival. METHODS:Out of 752 patients with STS (406 men and 346 women, average age 51 years), 310 patients were referre...

journal_title：Journal of surgical oncology

authors： Funovics PT,Vaselic S,Panotopoulos J,Kotz RI,Dominkus M

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Surgical procedures can cause tumor cells to disseminate into the circulatory system. Although this spread of metastatic cells will be limited by immune activity, immunosuppression tends to be the main effect resulting from surgery. The objective of this study is to assess hormonal and immunol...

journal_title：Journal of surgical oncology

authors： Boomsma MF,Garssen B,Slot E,Berbee M,Berkhof J,Meezenbroek Ede J,Slieker W,Visser A,Meijer S,Beelen RH

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Imatinib mesylate (IM) demonstrates substantial efficacy in most patients with metastatic gastrointestinal stromal tumors (GISTs). However, progression of GIST eventually develops and emerges as a challenge. To assess the role of surgery in the multidisciplinary management of GISTs, we studied the surgical outc...

journal_title：Journal of surgical oncology

authors： Yeh CN,Chen TW,Tseng JH,Liu YY,Wang SY,Tsai CY,Chiang KC,Hwang TL,Jan YY,Chen MF

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Significant controversy exists concerning the factors affecting survival after secondary cytoreduction (SCR) in recurrent ovarian cancer. This study aims to identify factors independently associated with survival after SCR. METHODS:We retrospectively retrieved 39 patients with recurrent ovarian cancer. All p...

journal_title：Journal of surgical oncology

authors： Biliatis I,Haidopoulos D,Rodolakis A,Vlachos G,Protopapas A,Thomakos N,Sergentanis T,Akrivos N,Antsaklis A

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:A treatment option for patients with peritoneal mucinous carcinomatosis (PMCA) from an appendiceal neoplasm is cytoreductive surgery and perioperative intraperitoneal chemotherapy. Also, these patients are recommended for systemic chemotherapy using an oxaliplatin and 5-fluorouracil (FOLFOX) regimen. A major...

journal_title：Journal of surgical oncology

authors： Sugarbaker PH,Bijelic L,Chang D,Yoo D

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:The number of incidentally discovered adrenal lesions is increasing due to the widespread use of abdominal imaging. Although most incidentalomas are benign, larger suspicious lesions will require adrenalectomy. The aim of this study is to determine the risk of malignancy in patients undergoing surgery for ...

journal_title：Journal of surgical oncology

authors： O'Neill CJ,Spence A,Logan B,Suliburk JW,Soon PS,Learoyd DL,Sidhu SB,Sywak MS

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To report on the clinical presentation and outcome for 234 patients with extra-abdominal desmoids tumors. METHODS:Since 1977, the authors have treated 234 patients with extra-abdominal desmoid tumors. The patients had an average age of 36.7 and 61% were female. The tumors arose adjacent to muscle...

journal_title：Journal of surgical oncology

authors： Mankin HJ,Hornicek FJ,Springfield DS

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Interleukin (IL)-1α and hepatocyte growth factor (HGF) play an important role in pancreatic cancer proliferation, angiogenesis, and invasiveness. The aim of this study was to investigate the cooperative role of HGF and IL-1α in metastatic processes promoted by interactions between pancreatic c...

journal_title：Journal of surgical oncology

authors： Xu D,Matsuo Y,Ma J,Koide S,Ochi N,Yasuda A,Funahashi H,Okada Y,Takeyama H

更新日期：2010-10-01 00:00:00

abstract：:Delphian node (DN) refers to the pre-laryngeal or pre-cricoid nodal tissue often identified during laryngeal or thyroid surgery. The original nomenclature is based on the assumption that metastasis to this node was predictive of aggressive disease and poor outcome for patients. In this article, we review the existing ...

journal_title：Journal of surgical oncology

authors： Iyer NG,Shaha AR,Ferlito A,Thomas Robbins K,Medina JE,Silver CE,Rinaldo A,Takes RP,Suárez C,Rodrigo JP,Bradley PJ,Werner JA

更新日期：2010-09-15 00:00:00

abstract：BACKGROUND:Lateral lymph node (LLN) metastasis sometimes occurs in patients with early rectal cancer that has invaded the submucosa (SM) and muscularis propria (MP). This study aims to identify the risk factor(s) for LLN metastasis in such patients. METHOD:We retrospectively analyzed 65 patients with pathological SM o...

journal_title：Journal of surgical oncology

authors： Homma Y,Hamano T,Otsuki Y,Shimizu S,Kobayashi H,Kobayashi Y

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyro...

journal_title：Journal of surgical oncology

authors： Martinez SR,Beal SH,Chen A,Chen SL,Schneider PD

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Reports of clinicopathological features and prognosis in patients with mucinous gastric carcinoma (MGC) are conflicting. The aim was to describe the clinicopathological features and prognosis of patients with MGC in comparison with nonmucinous gastric carcinoma (NMGC). METHODS:We reviewed the...

journal_title：Journal of surgical oncology

authors： Zhang M,Zhu GY,Zhang HF,Gao HY,Han XF,Xue YW

更新日期：2010-07-01 00:00:00

abstract：:The primary modality of treatment for a localized soft tissue sarcoma is surgical resection. Adjuvant or neoadjuvant radiation helps reduce the rate of local recurrence. The rate of limb preserving resection is 94% in our series. Local recurrence can be re-excised in 95% of the patients, with limb preservation in 90%....

journal_title：Journal of surgical oncology

authors： Karakousis CP

更新日期：2010-06-15 00:00:00

abstract：:Although the incidence of locally recurrent colorectal cancer has been reduced by improved surgical techniques and the frequent use of multimodality therapy, pelvic recurrence remains a significant problem. Radiation or chemotherapy may provide palliation but it is often short-lived. For fit candidates without evidenc...

journal_title：Journal of surgical oncology

authors： Varker KA,Wanebo HJ

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:Fine-needle aspiration biopsy (FNAB) is an emerging technique for diagnosis of bone and soft tissue lesions. While multiple studies have demonstrated efficacy, cost-effectiveness, and convenience, none have attempted to determine if the modality leads to an increased rate of local recurrence. Our objective w...

journal_title：Journal of surgical oncology

authors： Kaffenberger BH,Wakely PE Jr,Mayerson JL

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Recently, we have shown in a murine model that radiofrequency ablation (RFA) induces accelerated outgrowth of colorectal micrometastases in the transition zone (TZ) surrounding the ablated lesion. Conversely, RFA also induces an anti-tumor T-cell response that may limit tumor growth at distant sites. Here we...

journal_title：Journal of surgical oncology

authors： Nijkamp MW,Borren A,Govaert KM,Hoogwater FJ,Molenaar IQ,van Diest PJ,Kranenburg O,Borel Rinkes IH

更新日期：2010-06-01 00:00:00